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An important adverse event associated with bupropion use is seizureWith the IR formulationthe rate is 0.44/1000at doses of 300 to 450 mg/dayhoweverthe rate increases substantially at doses above this levelWith the SR formulationthe rate is 0.11/1000at the target dose of 300 mg/day4 The incidence of seizure with bupropion XL has not been evaluatedBupropion is not the only antidepressant associated with seizuresSSRI antidepressants are associated with seizure at a similar rate of approximately 0.14 Certain factors may increase the risk of seizurethereforeprior to the prescription of bupropionpatients should be screened for the presence of medical comorbiditiesclinical situationsor concomitant medications that viagra model. may lower seizure threshold.

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