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The Women’s Health InitiativeWHIestrogen-alone substudy reported increased risks of stroke and deep vein thrombosisDVTin postmenopausal women with daily oral conjugated estrogensCEaloneThe WHI estrogen-plus-progestin substudy reported increased risks of DVTpulmonary embolismstrokeand myocardial infarction in postmenopausal women with daily oral CE combined with medroxyprogesterone acetateMPAIn the absence of comparable datathese risks should be assumed to be similar for other dosage forms of estrogens.

The safety and efficacy of Estrace tablets in geriatric patients has not been establishedIn generaldose selection for an elderly patient should be cautioususually starting at the low end of the dosing rangereflecting the greatest frequency of decreased hepaticrenal or cardiac functionand of concomitant disease or other drug therapy.

Estrogen administration should be initiated at the lowest dose approved for the indication and then guided by clinical response rather than by serum hormone levelse.gestradiolFSHSee DOSAGE AND ADMINISTRATION section

NOTEThe number of doses per tube will vary with dosage requirements and patient handling.

20Schwartz JFreeman RFrishman WClinical pharmacology of estrogenscardiovascular actions and cardioprotective benefits of replacement therapy in postmenopausal womenJ Clin Pharmacol 3519951-16.

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